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Study Shows How Prostate Cancer Cells Mimic Osteoblasts

As prostate cancer expands to reach the bones, it often becomes fatal. The process at the back of this fatal element might possibly be used against this cancer type as an objective in bone-targeting radiation and possible novel therapies. This research is recently published in the journal PLOS ONE. In this study, researchers from the Duke Cancer Institute described how prostate cancer cells develop their ability to imitate bone-forming cells named osteoblasts. This quality enables the cancer-causing cells to grow in the bone microenvironment.

Attacking these cells with the help of radium-233, which is a radioactive isotope that can selectively target cells in these bone metastases, has been revealed to extend patients’ lives. However, a better comprehension of the working of radium in the bone was required. The mapping of this mimicking process might trigger a more effectual use of radium-233. It will as well lead to the development of novel therapies to treat or avoid the spread of prostate cancer to bone.

On a similar note, a global team of scientists is getting nearer to perfecting molecule-sized motors. According to scientists, these motors will have the capability to drill through the surface of cancer cells to kill them in an instant. Scientists from the Durham (U.K.) University, the Rice University, and North Carolina State University revealed their success at activating the motors. Reportedly, these motors were activated with precise two-photon excitation using near-infrared light. Dissimilar to the ultraviolet light they first employed to drive the motors, the novel technique does not harm neighboring healthy cells. The results of this research can be accessed in the journal ACS Nano.

This research was headed by chemists James Tour, Rice University, Robert Pal, Durham University, and Gufeng Wang, North Carolina State University. This study might be best applied to oral, skin, and gastrointestinal cancer cells that can be reached with a laser for treatment.

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